For all profiling needs, OncoHelix’ s exclusive test facility, HTL, uses validated and well-established panels from industry leading technology partners.
NGS Panels
AVENIO® 324 gene CGP Panel Matched to FoundationONE® CDx Panel
The AVENIO® 324 gene CGP panel analysis is powered by FoundationONE® Analysis Platform
Small Variants (306): ABL1, ACVR1B, AKT1, AKT2, AKT3, ALK, ALOX12B, AMER1, APC, AR, ARAF, ARFRP1, ARID1A, ASXL1, ATM, ATR, ATRX, AURKA, AURKB, AXIN1, AXL, BAP1, BARD1, BCL2, BCL2L1, BCL2L2, BCL6, BCOR, BCORL1, BRAF, BRCA1, BRCA2, BRD4, BRIP1, BTG1, BTG2, BTK, C11orf30, CALR, CARD11, CASP8, CBFB, CBL, CCND1, CCND2, CCND3, CCNE1, CD22, CD274, CD70, CD79A, CD79B, CDC73, CDH1, CDK12, CDK4, CDK6, CDK8, CDKN1A, CDKN1B, CDKN2A, CDKN2B, CDKN2C, CEBPA, CHEK1, CHEK2, CIC, CREBBP, CRKL, CSF1R, CSF3R, CTCF, CTNNA1, CTNNB1, CUL3, CUL4A, CXCR4, CYP17A1, DAXX, DDR1, DDR2, DIS3, DNMT3A, DOT1L, EED, EGFR, EP300, EPHA3, EPHB1, EPHB4, ERBB2, ERBB3, ERBB4, ERCC4, ERG, ERRFI1, ESR1, EZH2, FAM46C, FANCA, FANCC, FANCG, FANCL, FAS, FBXW7, FGF10, FGF12, FGF14, FGF19, FGF23, FGF3, FGF4, FGF6, FGFR1, FGFR2, FGFR3, FGFR4, FH, FLCN, FLT3, FOXL2, FUBP1, GABRA6, GATA3, GATA4, GATA6, GID4 (C17orf39), GNA11, GNA13, GNAQ, GNAS, GRM3, GSK3B, H3F3A, HDAC1, HGF, HNF1A, HRAS, HSD3B1, ID3, IDH1, IDH2, IGF1R, IKBKE, IKZF1, INPP4B, IRF2, IRF4, IRS2, JAK1, JAK2, JAK3, JUN, KDM5A, KDM5C, KDM6A, KDR, KEAP1, KEL, KIT, KLHL6, KMT2A (MLL), KMT2D (MLL2), KRAS, LTK, LYN, MAF, MAP2K1, MAP2K2, MAP2K4, MAP3K1, MAP3K13, MAPK1, MCL1, MDM2, MDM4, MED12, MEF2B, MEN1, MERTK, MET, MITF, MKNK1, MLH1, MPL, MRE11A, MSH2, MSH3, MSH6, MST1R, MTAP, MTOP, MUTYH, MYC, MYCL, MYCN, MYD88, NBN, NF1, NF2, NFE2L2, NFKBIA, NKX2-1, NOTCH1, NOTCH2, NOTCH3, NPM1, NRAS, NT5C2, NTRK1, NTRK2, NTRK3, P2RY8, PALB2, PARK2, PARP1, PARP2, PARP3, PAX5, PBRM1, PDCD1, PDCD1LG2, PDGFRA, PDGFRB, PDK1, PIK3C3B, PIK3C3G, PIK3CA, PIK3CB, PIK3R1, PIM1, PMS2, POLD1, POLE, PPARG, PPP2R1A, PPP2R2A, PRDM1, PRKAR1A, PRKCI, PTCH1, PTEN, PTPN11, PTPRO, QKI, RAC1, RAD21, RAD51, RAD51B, RAD51C, RAD51D, RAD52, RAD54L, RAF1, RARA, RB1, RBM10, REL, RET, RICTOR, RNF43, ROS1, RPTOR, SDHA, SDHB, SDHC, SDHD, SETD2, SF3B1, SGK1, SMAD2, SMAD4, SMARCA4, SMARCB1, SMO, SNCAIP, SOCS1, SOX2, SOX9, SPEN, SPOP, SRC, STAG2, STAT3, STK11, SYK, TBX3, TEK, TET2, TIPARP, TNFAIP3, TNFRSF14, TP53, TSC1, TSC2, TYRO3, U2AF1, VEGFA, VHL, WHSC1, WHSC1L1, WT1, XPO1, XRCC2, ZNF217, ZNF703
RNA Fusion (36): ALK, BCL2, BCR, BRAF, BRCA1, BRCA2, CD74, EGFR, ETV4, ETV5, ETV6, EWSR1, EZR, FGFR1, FGFR2, FGFR3, KIT, KMT2A (MLL), MSH2, MYB, MYC, NOTCH2, NTRK1, NTRK2, NUTM1, PDGFRA, RAF1, RARA, RET, ROS1, RSPO2, SDC4, SLC34A2, TERC, TERT, TMPRSS2
COMPREHENSIVE 170-gene Panel for Solid Tumour includes:
Specimen compatibility: Genomic DNA & RNA extracted from fresh frozen and FFPE tissues
DNA GENES ALONE:
Small variants and indel (148): AKT1, AKT2, AKT3, ALK, APC, AR, ARID1A, ATM, ATR, BAP1, BARD1, BCL2, BCL6, BRAF, BRCA1, BRCA2, BRIP1, BTK, CARD11, CCND1, CCND2, CCNE1, CD79A, CD79B, CDH1, CDK12, CDK4, CDK6, CDKN2A, CEBPA, CHEK1, CHEK2, CREBBP, CSF1R, CTNNB1, DDR2, DNMT3A, EGFR, EP300, ERBB2, ERBB3, ERBB4, ERCC1, ERG, ESR1, EZH2, FAM175A, FANCI, FANCL, FBXW7, FGF1, FGF10, FGF2, FGF23, FGF3, FGF4, FGF5, FGF7, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, FLT1, FLT3, FOXL2, GNA11, GNAQ, GNAS, HNF1A, HRAS, IDH1, IDH2, INPP4B, JAK2, JAK3, KDR, KIT, KRAS, MAP2K1, MAP2K2, MCL1, MDM2, MDM4, MET, MLH1, MLLT3, MPL, MRE11A, MSH2, MSH3, MSH6, MTOR, MUTYH, MYC, MYCN, MYD88, NBN, NF1, NOTCH1, NOTCH2, NOTCH3, NPM1, NRAS, NRG1, PALB2, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PIK3CD, PIK3CG, PIK3R1, PMS2, PTCH1, PTEN, PTPN11, RAD51B, RAD51C, RAD54L, RB1, RET, RICTOR, ROS1, SLX4, SMAD4, SMARCB1, SMO, STK11, TET2, TP53, TSC1, TSC2
DNA amplification target genes (59): AKT2, ALK, AR, ATM, BRAF, BRCA1, BRCA2, CCND1, CCND3, CCNE1, CDK4, CDK6, CHEK1, CHEK2, EGFR, ERBB2, ERBB3, ERCC1, ERCC2, ESR1, FGF1, FGF10, FGF14, FGF19, FGF2, FGF23, FGF3, FGF4, FGF5, FGF6, FGF7, FGF8, FGF9, FGFR1, FGFR2, FGFR3, FGFR4, JAK2, KIT, KRAS, LAMP1, MDM2, MDM4, MET, MYC, MYCL1, MYCN, NRAS, NRG1, PDGFRA, PDGFRB, PIK3CA, PIK3CB, PTEN, RAF1, RET, RICTOR, RPS6KB1, TFRC
OR
DNA GENES LISTED ABOVE PLUS RNA GENES:
RNA fusion target genes (55): ABL1, AKT3, ALK, AR, AXL, BCL2, BRAF, BRCA1, BRCA2, CDK4, CSF1R, EGFR, EML4, ERBB2, ERG, ESR1, ETS1, ETV1, ETV4, ETV5, EWSR1, FGFR1, FGFR2, FGFR3, FGFR4, FLI1, FLT1, FLT3, JAK2, KDR, KIF5B, KIT, KMT2A (MLL), MET, MLLT3, MSH2, MYC, NOTCH1, NOTCH2, NOTCH3, NRG1, NTRK1, NTRK2, NTRK3, PAX3, PAX7, PDGFRA, PDGFRB, PIK3CA, PPARG, RAF1, RET, ROS1, RPS6KB1, TMPRSS2
FOCUSED 7-gene Panel for Solid Tumour such as Prostate, Bladder, Cholangiocarcinoma includes:
Specimen compatibility: Genomic DNA and RNA extracted from fresh frozen and FFPE tissues
DNA amplification target genes: BRCA 1, BRCA2, ATM, FGFR 1, FGFR 2, FGFR 3, FGFR 4
FOLLOW IT ® 38-gene ctDNA Panel for Solid Tumour includes:
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Specimen compatibility: Genomic DNA extracted from fresh blood sample
SNVs, deletions and insertions (up to 24bp):
AKT1: E17, ALK: T1151, L1152, C1156, F1174, L1196, L1198, G1202, D1203, S1206, G1269, R1275, Y1278 AR: L702H, V716, S741, W742, Q784, H875, F877, T878, M896 BRAF: Q201, G464, G466, F468, G469, Y472, D594, F595, G596, L597, V600, K601, part of Exon 15 (V600-M620), G606, CCNE: Amplification, CTNNB1: D32, S33, G34, I35, H36, S37, T41, S45, DDR2: L239, I638, S768, DICER1: D1705-D1709, G1809, D1810-E1813, EGFR: R108, A289, S492, P596, G598, Exon18, Exon19, Exon20, Exon21, & Amplification, ERBB2: G309, S310, K753, L755, I767, D769, Exon 20, & Amplification, ESR1: K303, E380, S463, V534, P535, L536, Y537, D538, FGFR1: N546, K656, & Amplification, FGFR2: S252, P253, W290, A315, S372, Y375, C382, N549, K659, E731, E777, & Amplification, FGFR3: R248, S249, G370, S371, Y373, G380, A391, 650, FOXL2: C134, GNA11: Q209, GNAQ: Q209, GNAS: R201, HRAS: G12, G13, Q61, IDH1: R132, IDH2: R140, R172, KIT: S476, Y553, W557 559, V560, L576, K642, V654, T670, D816, D820, N822, Y823, A829, Exon9, Exon11, Exon13, & Amplification, KRAS: K5, A11, G12, G13, L19, Q22, A59, G60, Q61, K117, A146, & Amplification, MAP2K1(MEK1): F53, Q56, K57, K59, V0, D67, I103, I111, C121, N122, P124, P387, MAP2K2(MEK2): F57, Q60, K61, L119, H123, G132, MET: T1010, V1112, H1112, G1181, L1213, D1246, Y1248, Y1253, Exon13, Exon 14 (-50 to +25), Exon18, & Amplification, NRAS: G12, G13, A59, G60, Q61, K117, A146, NTRK1: F589, G595, G667, NTRK3: G623, G696, PDGFRA: R560-E571, P577, N659, D842, L839-Y849, PIK3CA: R88, C90, R93, P104, G106, N107, R108, K111, R115, N345, R357, G364, E365, Exon6 [start to P377], C420, E453, P539, E542, E545, Q546, D549, E970, E978, M1043, N1044, A1046, H1047, G1049, & Amplification, POLE: Exon9, Exon10, Exon11, Exon12, Exon13, Exon14, (P286R, M295R, S297F, F367S, D368Y, V411L, L424I, M444K, A456P, S459F), PTCH1: W844, G1093, PTEN: A126, G129, R130, R173, R233, K254-K267, RET: G533, K603, C609, C611, C618, C620, C630, D631, C634, G691, E768, L790, Y791 V804, Y806, A886, S904, M918, A919, Exon10, Exon13, Exon15, ROS1: S1986, L2026, G2032, STK11: Q37, P281, TP53: Exon4, Exon5, Exon6, Exon7, Exon8, Exon9; MSI: 21Loci
Hematology Oncology Panel Includes:
Myeloid (DNA) Panel