Cytokine Panels

Contact OncoHelix to arrange for Cytokine Profile Testing at your center.

Click to view our Enhanced Cytokine Profile Report.
Click to view our Cytokine 2-Plex Report.
Requisition Form
OncoHelix provides the ability to determine a person’s cytokine profile to investigate and risk-stratify those individuals undergoing cytokine storm/cytokine release syndrome. Traditional single cytokine tests and cytogenetic assessment is limited and non-specific in predicting those patients at high risk for cytokine release syndrome or cytokine storm.
Cytokine Profiling Panels

INVESTIGATE and MONITOR the Storm with OncoHelix

At-risk patients for cytokine syndromes include:

  • CAR-T treatment related oncology patients
  • Acute inflammatory conditions like hemophagocytic lymphohistiocytosis (HLH)
  • COVID-19 related patients (see COVID-19 Cytokine Storm tab for more information)

Cytokine Profile Difference

Using a Luminex based serum immunologic test, performed by clinical diagnostic facilities of OncoHelix, three panels – Enhanced, 34-plex and 2-plex cytokine and soluble receptor profiling panels - identify:

  • Specific Cytokine profile compared to a baseline of 132 normal healthy people (unlike non-specific traditional cytokine tests)
  • Changes in an individual’s cytokine profile: monitoring of disease progression and/or therapy response
  • Investigation of an inflammatory disease
  • Diagnosis of acute inflammatory conditions like Hemophagocytic Lymphohistocytosis (HLH)
  • Investigation and monitoring of Cytokine Storm

Enhanced Cytokine & Soluble Receptor Profile:

34-PLEX Cytokine Panel

Analytes (pg/mL and reference ranges): Eotaxin/CCL11, GM-CSF, GRO alpha/CXCL1, IFN alpha, IFN gamma, IL-1 beta, IL-1 alpha, IL-1RA, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8/CXCL8, IL-9, IL-10, IL-12 p70, IL-13, IL-15, IL-17A, IL-18, IL-21, IL-22, IL-23, IL-27, IL-31, IP-10/CXCL10, MCP-1/CCL2, MIP-1 alpha/CCL3, MIP-1 beta/CCL4, RANTES/CCL5, SDF1 alpha/CXCL12, TNF alpha, TNF beta/LTA.
 

2-PLEX Soluble Receptor Panel

Analytes (pg/mL or ng/mL and reference ranges): sIL2Ra and sCD163

Anti-cytokine syndrome therapies

MONITOR for RESPONSE

OncoHelix can support cytokine profile panel testing to assess response to anti-cytokine (e.g., anti-IL-1, anti-IL-6 or anti-TNFa therapy) or other therapies with continued serum testing after treatment has been initiated.

Clinical Pathways

Cytokine Syndromes Testing and CAR-T Oncology Treatment

Cytokine Profiling Panels

CLINICAL GRADE Cytokine Profiling Facility

Hematology Translational Lab (HTL), Calgary, AB

The HTL is a is clinically accredited, province-wide utilized, and a trusted lab at the Arnie Charbonneau Cancer Institute in the University of Calgary, providing clinical grade cytokine profiling. HTL is official testing facility for OncoHelix.

Turn Around Time:

  • 2-week routine option
  • 48 hour ‘STAT’ option

Recommendations for ordering Cytokine Profile Panel based on Turn Around Time
Order Recommendations

References:

Shimabukuro-Vornhagen et al. Cytokine release syndrome
https://doi.org/10.1186/s40425-018-0343-9